Oxidative Pictet-Spengler cyclisations through acceptorless iridium-catalysed dehydrogenation of tertiary amines
نویسندگان
چکیده
The valuable tetrahydro-?- and ?-carboline skeleta can be accessed through Pictet-Spengler cyclisation initiated by acceptorless dehydrogenation of saturated cyclic amines. substrate scope for the ?-isomers is found to somewhat limited, but access ?-isomers more reactive 2-(aminoethyl)indoles general. synthetic utility hydrogen transfer catalysis highlighted in a two-step preparation alkaloid desbromoarborescidine A sequential redox-neutral alkylation/dehydrogenative cyclisation.
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2021
ISSN: ['0040-4020', '1464-5416']
DOI: https://doi.org/10.1016/j.tet.2020.131785